Huge congratulations to our colleagues led by Associate Professor Katarína Šebeková on the new paper on metabolic syndrome and its impact on the brain and behaviour in rats. Rats fed a cafeteria diet showed features resembling metabolic syndrome, higher concentrations of neuroinflammatory markers in the hypothalamus, impaired short-term memory and lower locomotor activity. Multivariate analysis showed that hypothalamic neuroinflammation, the severity of metabolic syndrome and a smaller corpus callosum volume are among the key predictors of cognitive and behavioural impairment, supporting the role of the metabolism–inflammation axis in brain vulnerability in metabolic syndrome.