Several of our colleagues have recently translated long-term collaborations into significant scientific publications in the field of Oncology.
The first publication was produced with a team of clinicians led by Associate Professor Michal Chovanec and Professor Michal Mego from the National Institute of Oncology in Bratislava and our colleagues (Associate Professor Barbora Vlková, Associate Professor Michal Pastorek and Professor Peter Celec) and shows that increased concentrations of biomarkers of intestinal microbial translocation, especially sCD14, are associated with higher severity of cisplatin-induced peripheral neuropathy in long-term survivors of testicular germ cell tumors, suggesting that disruption of the intestinal barrier during treatment may contribute to persistent neurotoxicity.
The second publication was created with colleagues from the Institute of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, colleagues from the Laboratory of Mitochondrial Physiology, Institute of Physiology, Czech Academy of Sciences in Prague, and Associate Professor Roman Gardlík and Doctor Alexandra Gaál Kovalčíková. They found that the synthetic chalcone derivative ZK-CH-11d selectively disrupts the mitochondrial metabolism of tumor cells, thereby inducing apoptosis and potentially reducing their metastatic potential, without affecting healthy cells.
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