Big congratulations to our colleagues Andrej Feješ and Katarína Šebeková on an outstanding publication, produced through international collaboration with the University of Vienna, which has uncovered a fascinating link between taste receptors and systemic inflammation in obesity. The results show that receptors for sweet taste and fatty acids in the oral cavity are closely associated with inflammatory changes in cafeteria diet-induced obesity, while the same receptors in the intestines or spleen do not show this connection. Reduced activity of these receptors may impair satiety signalling and contribute to a self-reinforcing cycle of overeating, weight gain, and inflammation.