We warmly congratulate our Doctor Barbora Gromová on her prestigious publication in the journal Cellular & Molecular Immunology, which was written during her several-month internship with Doctor Maria Serena Longhi at Harvard Medical School in Boston (United States of America). The publication shows that blockade of CD39-AS (antisense) RNA in T regulatory (Treg) cells leads to a decrease in glucose transport and glycolysis and to increased function and stability of Treg cells in inflammatory bowel diseases. In T helper type 17 cells, silencing of CD39-AS limits oxidative reactions and improves mitochondrial health. These metabolic effects are also noted in a model of experimental colitis in humanized mice, along with reduced disease activity.